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Sibutramine and Phentermine are the anorexigenic drugs intended for the obesity treatment in the combination with a diet and physical exercises.
Phentermine is a sympathomimetic means. The pharmacological effect of Phentermine is to increase noradrenaline and dopamine release in the central nervous system (the CNS) that causes the lack of appetite.
Sibutramine is a serotonergic means. In contrast to Phentermine, Sibutramine drug does not increase, but inhibits the reuptake of norepinephrine and serotonin.
Sibutramine and Phentermine may significantly affect cardiovascular system (CVS). Sibutramine and Phentermine have similar contraindications and most of them are associated with CVS.
Side effects of Sibutramine and Phentermine are also similar and they include: sleep disorder, headache, dry mouth, increased heart rate, tremor of limbs and mood changes.
Call your doctor at once if you experience any of the above-mentioned or other serious side effects.
Phentermine has been used as an obesity treatment since 1959. Phentermine is an active substance that is contained in many medications (such as, Duromine, Adipex-P, Qsymia).
In 1997, Sibutramine was approved as an obesity treatment in the USA under the trademark Meridia. After the large-scale clinical trials of Sibutramine, it was revealed a significant increase in the risk of cardiovascular diseases.
Therefore, in 2010 the FDA asked the Meridia manufacturer voluntarily to withdraw this drug from the U.S. pharmacological market. After Abbott Laboratories company removed its drug from the USA market.
At the beginning of 2014, Sibutramine is not used in most countries of the world for the treatment of obesity and weight loss (such as Canada, Australia, and the European Union).