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The efficacy of anti-obesity therapy lies in a complex approach to the problem solution. An imbalance between consumed and expended energy in the body provokes accumulation of fat tissue. To normalize energy balance, it is recommended to adhere to a rational diet and to increase physical activity.
If diet and intense physical activity do not cause weight loss, then a weight loss drug must be added to a non-drug obesity therapy. The first drug, which was used for weight loss was Phentermine. It is known that Phentermine slimming pills were first used in clinical practice in 1959.
Today Phentermine is sold under different trademarks in different countries. For instance, in the USA, this weight loss drug is available under the trademark Duromine, Metermine and Phentermine Resin.
Phentermine weight loss drug is meant for a short-term treatment of obesity in people with BMI 30 or higher. Phentermine can also be prescribed for obesity treatment in BMI 27 or higher, in the presence of comorbidities (diabetes mellitus, dyslipidemia and hypertension).
A sympathomimetic amine Phentermine stimulates the release of dopamine and norepinephrine in hypothalamus. Phentermine weight loss pills suppress the appetite and increase the feeling of satiety. In addition to appetite suppression, Phentermine improves metabolism and increases thermogenesis in the human body.
When using Phentermine slimming pills, a person needs minimal food to feel fullness. Hence, when using Phentermine pills, people consume fewer calories than usual. Given that Phentermine is prescribed in combination with intense physical activity, a negative energy balance is formed, providing weight loss.
A negative energy balance is formed when the body expends more calories than it gets with food. To lose weight, people should take Phentermine in short courses – within three months maximum. Phentermine weight loss capsules or tablets should be taken once in the morning on an empty stomach, or within 1-2 hours after meal.
It is recommended to begin an anti-obesity therapy with a single dose of Phentermine 30 mg. If Phentermine 30 mg causes side effects (dizziness, dry mouth, nausea, vomiting or diarrhea), then the dose of weight loss drug can be reduced down to a minimal daily dose of Phentermine 15 mg.
If Phentermine 30 mg does not provide a stable therapeutic effect, the daily dose can be increased up to a maximal allowable dose for obesity treatment – Phentermine 40mg. Exceeding the dose of Phentermine 40 mg may cause overdose and both physical and psychological dependence.
Phentermine appetite suppressant drug is prescribed for obesity treatment to adults and adolescents over 16 years old. When Phentermine is prescribed to people with hypertension, they should control the blood pressure regularly. In a persistent increase of the blood pressure, patients should reduce the dose of Phentermine.
In a simultaneous use of Phentermine and antihypertensive drugs, doctors recommend to control the blood pressure levels as well. Weight loss helps to reduce the blood pressure. Therefore, antihypertensive drugs (Acebutolol, Amlodipine, or Benazepril) should be taken in a low dosage during Phentermine anti-obesity therapy.
Along with the reduction of fat, Phentermine increases insulin sensitivity and reduces the blood sugar. Considering that Phentermine pills indirectly contributes to reduction of the blood sugar, oral hypoglycemic drugs (Glumetza, Fortamet, Riomet, Glucophage) should be used in a low dosage during the drug therapy of obesity.
It must be noted that to maintain the body weight at a normal level after the end of Phentermine anti-obesity therapy, people should stick to a balanced diet and make physical exercises. If a person returns to his old lifestyle after the termination of Phentermine pills, his kilograms will return as well. Obesity requires a constant control in nutrition and an active lifestyle.